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In previous work, I wrote about targeting proinflammatory pathway, JAK inhibition, targeting anti-inflammatory pathway and The transforming growth factor β (TGF–β) pathway. SMAD7 antisense oligonucleotide. Basically, it must be about targeting a certain pathway of the disease in immune perspective.
If JAK-stat inhibitions is the best go for it, if not then go for another pathway.
References must be published in 5 years only, five of them in experimental researches.