Why do viruses that have jumped hosts (such as from bats to humans) cause much m

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Why do viruses that have jumped hosts (such as from bats to humans) cause much more severe infection? Please discuss gene transduction and antigenic drift in virus.
The case study is meant to be a critical analysis of the course information as it relates to Virus and Immunology, it is not meant to be a series of direct or short answer responses. Please make sure to not only reference specific information by paraphrasing sources and then critically analyzing them in your own, unique analysis.
2.) What does “mast cell degranulation that causes speedy histamine and cytokine-driven inflammatory responses” mean in terms of immunology and the human body? How does this kind of inflammatory response occur in autoimmune diseases, and what similar kind of response occurs during Covid-19 infection?
3.) Describe the role of cytokines and interleukins in cell signaling cascades and the immune response? Why does this make the inflammatory response an important part of the immune response?

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